Method for producing 7-aminocephem compounds

Details Method for producing 7-aminocephem compounds Method for producing 7-aminocephem compounds

1981-11-06

1984-05-01

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 16, 544 21, 544 30, C07D50104, C07D50102

Patent

active

044463189

ABSTRACT:
An improvement, in per se known method for producing 7-aminocephem compound being important intermediate for producing antimicrobial substances, represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methoxy group and R.sup.2 is a residue of a thiol compound, or a salt or ester thereof, by reacting a compound of the formula: ##STR2## wherein R.sup.1 is as defined above and R is a carboxylic acid acyl group, or a salt or ester thereof, with a thiol compound or a salt thereof, is characterized in that the reaction is conducted in an organic solvent in the presence of a dihalophosphoric acid to give the compound [II] in high yield and high purity.

REFERENCES:
patent: 4312986 (1982-01-01), Saikawa et al.
patent: 4317907 (1982-03-01), Saikawa et al.

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