Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-pip

Details Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-pip Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-pip

1980-01-09

1981-06-02

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40514

Patent

active

042713005

ABSTRACT:
An improved method is disclosed for producing antihypertensively active 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] quinazoline hydrochloride, viz prazosine hydrochloride, by reacting methyl-N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]thiofo rmamidate with a large excess of ammonium chloride.

REFERENCES:
patent: 3935213 (1976-01-01), Hess
patent: 4092315 (1978-05-01), Bianco

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