Method for producing 5-aryl nicotinaldehydes

Details Method for producing 5-aryl nicotinaldehydes Method for producing 5-aryl nicotinaldehydes

2001-01-05

2009-11-24

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S318000, C546S319000, C546S339000, C546S341000

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active

RE041008

ABSTRACT:
The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.

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