Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2004-12-01
2010-06-15
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S310000
Reexamination Certificate
active
07737275
ABSTRACT:
A process is described for preparing 3-phenyl(thio)uracils or 3-phenyldithiouracils of the formula I, by reacting a phenyl iso(thio)cyanate of the formula II with an enamine of the formula III and, if appropriate, in a further step, the resulting 3-phenyl(thio)uracil or 3-phenyldithiouracil of the formula I where R1=R1a, when R1=hydrogen, is reacted with an aminating agent of the formula IV to give 3-phenyl(thio)uracils or 3-phenyldithiouracils of the formula I where R1=aminowhere the variables R1, R1a, R2, R3, R4, X1, X2, X3, Ar, A and L1 are each as defined in claim1.
REFERENCES:
patent: 4309209 (1982-01-01), Kobzina
patent: 4943309 (1990-07-01), Bell
patent: 5169430 (1992-12-01), Strunk et al.
patent: 6184183 (2001-02-01), Andree et al.
patent: 6207830 (2001-03-01), Sting
patent: 2004/0235665 (2004-11-01), Zagar et al.
patent: 2083071 (1993-06-01), None
patent: 2 485 360 (2003-11-01), None
patent: 19741411 (1998-03-01), None
patent: 0831091 (1998-03-01), None
patent: WO01/83459 (2001-11-01), None
patent: WO 01/83459 (2001-11-01), None
patent: WO03/240221 (2003-03-01), None
patent: WO 03/097589 (2003-11-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Kamal El-Dean et al., “Synthesis of Pyrimidines, Thienopyrimidines and Pyrazolopyrimidine”, Journal of the Chinese Chemical Society, 2002, 49, 1057-1060.
Cervello et al., “An Improved Method for the Synthesis of Sulfonylureas”, Synthesis, Mar. 1990, pp. 221-222.
Schwenkkraus et al., “Properties and Reactions of Substituted 1, 2-Thiazetidine 1, 1-Dioxides: Alkylation and Acylation of 3-Haloalkyl β-Sultams and Synthesis of Bicyclic β-SuRams”, Arch. Pharm., 326, 437-441 (1993).
B.A. Arbuzov et al., “Bulletin of the Academy of Sciences of the USSR Division of Chemical Science”, 39, 1990, 2610.
Sowada et al, “Über die Alkylierung 1,3-disubstituierter Schwefelsäurediamide”, J. Prakt. Chem. 25, 1964, 88-94.
Unterhalt et al. “Trialkyl-und Tetraalkylsulfonyldiamide”, Arch Pharm, 314,1981, 51-57.
Bancroft, “Synthesis and Reduction of Some 1,H-2,1,3-Benzothiadiazin-4(3H)one 2,2-Dioxides”, J. Het. Chem., Dec. 15, 1978, 1521-1523.
Martinez et al., “Chlorophenylmethyl Benzothiadiazine Dioxides Derivatives: Potent Human Cytomegalovirus Inhibitors”, Bioorganic & Medicinal Chemistry Letters, 9, (1999), 3133-3136.
Hamprecht Gerhard
Keil Michael
Mayer Guido
Puhl Michael
Reinhard Robert
BASF - Aktiengesellschaft
Murray Jeffrey H
Rothwell Figg Ernst & Manbeck P.C.
Wilson James O
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