Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1997-02-12
1998-06-09
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435121, 435822, 435880, C12P 1712
Patent
active
057632324
ABSTRACT:
A method for producing a 3-hydroxy nitrogen-containing six-membered cyclic compound is provided. Namely, microbial cells of a microorganism and/or a preparation obtained from the microbial cells is allowed to act on a nicotinic acid derivative or a 2-pyrazinecarboxylic acid derivative represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, representing hydrogen atom, halogen atom, hydroxyl group, amino group, carboxyl group, cyano group, oxime group, or alkyl group having a number of carbon atom or atoms of 1 to 5 respectively, and A represents carbon atom or nitrogen atom, the microbial cells and/or the preparation obtained from the microbial cells having an ability to perform hydroxylation of the nicotinic acid derivative or the 2-pyrazinecarboxylic acid derivative accompanied by decarboxylation of carboxyl group.
REFERENCES:
patent: 4738924 (1988-04-01), Kulla et al.
patent: 5151351 (1992-09-01), Hoeks et al.
patent: 5273893 (1993-12-01), Kiener
patent: 5516661 (1996-05-01), Kiener
Nagasawa Toru
Sakamoto Takeshi
Sashida Reiko
Takai Yukie
Ueda Makoto
Lilling Herbert J.
Mitsubishi Chemical Corporation
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