Method for producing 20-deoxotylosin

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 691, 435 711, 435 91, 435169, 4351721, 4351723, 43525235, 4353201, 435886, 536 71, 536 27, 935 6, 935 14, 935 22, 935 29, 935 38, 935 39, 935 40, 935 42, 935 59, 935 60, 935 61, 935 75, C12P 1900, C12N 121, C12N 1552, C12N 1576

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active

051680521

ABSTRACT:
The present invention, utilizing recombinant DNA technology, provides a novel method for obtaining 20-deoxotylosin from a tylosin producing microorganism. 20-deoxotylosin is useful as an antibiotic with a microbial inhibitory activity similar to tylosin.

REFERENCES:
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Chater et al., 1985, The EMBO J. 4:1893-1897.
Nature, 314:642-644 (1985) Hopwood, et al.
Nature, 309:462-464 (1984) Malpartida and Hopwood.
Antimicrobial Agents and Chemotherapy 20:214-225 (1981) Baltz and Seno.
In Protein Engineering 365 Inouye and Sarma ed., Academic Press, Inc. Baltz, et al. (1986).
Journal of Antibiotics 36:131 (1982) Baltz, et al.
Journal of Natural Products 49:971 (1986) Cox, et al.
Proc. Natl. Acad. Sci. USA 84:8248 (1987) Fishman, et al.

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