Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-01-17
2011-10-04
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S327500
Reexamination Certificate
active
08030338
ABSTRACT:
It is an object to provide a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain, which is suitable for production of a derivative having a radioisotope.A method for producing 1-(1-benzoyloxymethyl-2-hydroxyethyl)oxymethyl-2-nitroimidazole, characterized by reacting glycerin with a benzoylating agent to obtain 1-O-benzoylglycerin, reacting 1-O-benzoylglycerin with dimethoxymethane in the presence of a dehydrating agent to obtain 4-benzoyloxymethyl-1,3-dioxolane, and then reacting this product with 2-nitroimidazole or 2-nitro-1-trialkylsilylimidazole in the presence of a Lewis acid.
REFERENCES:
patent: 4945102 (1990-07-01), Suzuki et al.
patent: 5064849 (1991-11-01), Suzuki et al.
patent: 6743925 (2004-06-01), Takai et al.
patent: 1 110675 (1989-04-01), None
patent: 2-48549 (1990-02-01), None
patent: 3-223258 (1991-10-01), None
patent: 6-228123 (1994-08-01), None
patent: 06-228123 (1994-08-01), None
patent: 6-279415 (1994-10-01), None
patent: 2003 509413 (2003-03-01), None
patent: 2005-538030 (2005-12-01), None
patent: WO 01/97860 (2001-12-01), None
patent: WO 01/97860 (2001-12-01), None
Abstract of Aragozzini et al, “Enatioselective microbial reduction of monoesters of 1,3-dihydroxypropane: Synthesis of (S)-and (R)-1,2-O-isopropylideneglycerol,” Synthesis (1989), vol. 3, pp. 225-227.
Takekuma et al, “Preparation of 1-O-Benzoylglycerol and its Effect on the Formation of the Fruit Body of Tokiirohiratake,” Chem. Society of Japan (2001), vol. 1, pp. 61-64.
Wada, Hiroaki et al., “Synthesis of 1-[2-[18F]Fluoro-1-(hydroxymethyl)-ethoxy]methyl-2-nitroimidazole ([18FENI), a Potential Agent for Imaging Hypoxic Tissues by PET”, Journal of Labelled Compounds and Radiopharmaceuticals, vol. 43, No. 8, pp. 785-793, (2000).
Coppins Janet L
McKane Joseph K.
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Pola Pharma Inc.
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