Method for producing 2,4-dihydroxyquinoline derivatives

Details Method for producing 2,4-dihydroxyquinoline derivatives Method for producing 2,4-dihydroxyquinoline derivatives

1988-04-04

1990-02-27

Dixon, Jr., William R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D215220

Patent

active

049047876

ABSTRACT:
A method for producing a 2,4-dihydroxyquinoline derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom, and its tautomer, which comprises cyclizing an aryl malonic acid amide ester derivative of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, and R.sup.5 is a lower alkyl group, by means of polyphosphoric acid.

REFERENCES:
Chemical & Pharmaceutical Bulletin, vol. 29, No. 8, Aug. 1981, pp. 2161-2165; M. Tominaga et al.

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