Method for producing...

Details Method for producing... Method for producing...

2006-04-25

2006-04-25

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07034155

ABSTRACT:
N-ethyl-N-[3-(3-cyanopyrazolo[1,5-a]pyrimidine-7-yl)phenyl]acetamide (Zaleplon) can be produced by condensing 3-(N-acetyl-N-ethyl-amino)-β-oxo-phenylpropanal sodium salt with 3-amino-4-cyanopyrazole. Said sodium salt can be produced by first treating 3-acetylamino-acetophenone with an alkali metal hydroxide, in particular with powdered potassium hydroxide and then with an ethylating reagent, in particular ethyl bromide and the N-(3-acetylphenyl)-N-ethyl-acetamide that is obtained is reacted with a formic acid alkyl ester in the presence of an alkali metal alkanolate, in particular in the presence of sodium ethanolate. Zaleplon is the active ingredient of the soporific licensed under the trade name Sonata®.

REFERENCES:
patent: 4626538 (1986-12-01), Dusza et al.
patent: 0776898 (1997-06-01), None

Affiliated with

Also associated with

Rating

Method for producing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3581403