Method for producing...

Details Method for producing... Method for producing...

2005-05-10

2005-05-10

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

active

06891041

ABSTRACT:
A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.

REFERENCES:
patent: 4251528 (1981-02-01), Brittain et al.
patent: 5849741 (1998-12-01), Watanabe et al.
patent: 6114530 (2000-09-01), Yuan et al.
patent: 6340684 (2002-01-01), Napoletano et al.
patent: 6706882 (2004-03-01), Napoletano
patent: 634404 (1995-01-01), None
patent: 9835958 (1998-08-01), None
patent: 9932456 (1999-07-01), None
patent: 0005218 (2000-02-01), None
Napoletano et al. Bioorganic & Medicinal Chemistry Letters vol. 11, p. 33-37 (2001).

Affiliated with

Also associated with

Rating

Method for producing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3426671