Method for producing 1-substituted-5-acylimidazole compound

Details Method for producing 1-substituted-5-acylimidazole compound Method for producing 1-substituted-5-acylimidazole compound

2006-08-22

2010-12-28

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S399000

Reexamination Certificate

active

07858807

ABSTRACT:
Disclosed is a commercially suitable method for producing a 1-substituted-5-acylimidazole compound. A 1-substituted-5-acylimidazole compound is produced with a high position selectivity by reacting an N-substituted amidine compound or a salt thereof with a ketone compound in the presence of a base.

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Reiter et al. “Synthesis of 4(5)-acyl-, 1-substituted 5-acyl- and 1-substituted 4-acyl-1H-imidazoles from 4-aminoisoxazoles” Journal of Organic Chemistry 52:2714-2726 (1987).
Supplementary European Search Report issued in the corresponding European Patent Application No. 06796645.7 (Mar. 29, 2010).

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