Method for producing 1,2-benzisothiazol-3-ones

Details Method for producing 1,2-benzisothiazol-3-ones Method for producing 1,2-benzisothiazol-3-ones

1995-06-06

1997-05-27

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27504

Patent

active

056333846

ABSTRACT:
A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.

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"An Improved Method for the Preparation of 2-Substituted 1,2-Benzisothiazol-3(2H)-Ones. Novel Cyclization of N-Substituted 2-Carbamoylbenzenesulfenyl Bromides on Activated Basic Alumina," Kamigata et al., Organic Preparations and Procedures Int., 15(5), 315-319 (1983).
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