Method for processing mass analysis data and mass spectrometer

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S281000, C250S282000, C250S287000

Reexamination Certificate

active

08044347

ABSTRACT:
Intensity data of the signals produced by an ion detector are sequentially stored in a data processor, with each piece of intensity data being associated with time t required for each of the various ions ejected from an ion trap to fly through a time-of-flight space and reach the ion detector. The data obtained within a time range T2corresponding to a measurement mass range are extracted as profile data. The data obtained within either a time range T1before the arrival of an ion having the smallest m/z value or a time range T3after the arrival of an ion having the largest m/z value are extracted as noise component data. Various kinds of noise information such as the noise level or standard deviation are calculated from the noise component data. Based on this noise information, a noise component is removed from the profile data. For every mass scan cycle, the noise component data and profile data are almost simultaneously obtained. Therefore, even if the electrical noise from the ion detector changes with time, the noise can be properly removed with little influence from that change of the noise.

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Dmitriy Petrov, et al., “Compression for LC-MS Data, acquired on high resolution ESI-o-TOF-MS,” Abstracts of the 16th International Mass Spectrometry Conference, 2003.
Alpha Ltd. Co, “Alpha Ltd. Co Research consulting Mass Spectrometry development and applications,” 2003, <http://www.alpha-ms.com/references.htm>.

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