Method for processing aqueous fermentation broths

Details Method for processing aqueous fermentation broths Method for processing aqueous fermentation broths

1989-04-06

1991-06-18

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435243, 435246, 435812, 435942, 210631, C12N 100, C12N 134, C12R 1865

Patent

active

050249371

ABSTRACT:
A method for processing aqueous fermentation broths in a bioreactor vessel, in which a foam inhibitor is added to the fermentation broth in the bioreactor vessel in order to prevent the accumulation and buildup of foam in the bioreactor vessel caused by oxygen sparging of the fermentation broth contained therein. The aqueous fermentation broth processed in the bioreactor vessel is conveyed as a feed solution to an ultrafiltration system including a membrane for concentrating the aqueous fermentation broth. The ultrafiltration system is typically located downstream of the bioreactor vessel. The improvement involves reducing the amount of fouling of the membrane in the ultrafiltration system by adding to the aqueous fermentation broth in the bioreactor vessel as the foam inhibitor, an antifoam which is an oil based liquid in the form of droplets, the droplets of the oil based liquid antifoam being dispersed, encased, entrapped, and imbedded, within solid particles of a water soluble encapsulating material.

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"Controlled Release from Cornstarch", AG Consultant, Fall 1987, p. 12.

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