Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2007-06-26
2007-06-26
Smith, Ruth S. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S476000, C600S477000, C436S063000, C436S064000, C436S813000
Reexamination Certificate
active
10688152
ABSTRACT:
Fluorescence spectral data acquired from tissues in vivo or in vitro is processed in accordance with a multivariate statistical method to achieve the ability to probabilistically classify tissue in a diagnostically useful manner, such as by histopathological classification. The apparatus includes a controllable illumination device for emitting electromagnetic radiation selected to cause tissue to produce a fluorescence intensity spectrum. Also included are an optical system for applying the plurality of radiation wavelengths to a tissue sample, and a fluorescence intensity spectrum detecting device for detecting an intensity of fluorescence spectra emitted by the sample as a result of illumination by the controllable illumination device. The system also include a data processor, connected to the detecting device, for analyzing detected fluorescence spectra to calculate a probability that the sample belongs in a particular classification. The data processor analyzes the detected fluorescence spectra using a multivariate statistical method. The five primary steps involved in the multivariate statistical method are (i) preprocessing of spectral data from each patient to account for inter-patient variation, (ii) partitioning of the preprocessed spectral data from all patients into calibration and prediction sets, (iii) dimension reduction of the preprocessed spectra in the calibration set using principal component analysis, (iv) selection of the diagnostically most useful principal components using a two-sided unpaired student's t-test and (v) development of an optimal classification scheme based on logistic discrimination using the diagnostically useful principal component scores of the calibration set as inputs.
REFERENCES:
patent: 5421339 (1995-06-01), Ramanujam et al.
patent: 5612540 (1997-03-01), Richards-Kortum et al.
patent: 5660181 (1997-08-01), Ho et al.
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 6095982 (2000-08-01), Richards-Kortum et al.
patent: 6135965 (2000-10-01), Tumer et al.
patent: 6174291 (2001-01-01), McMahon et al.
patent: 6241662 (2001-06-01), Richards-Kortum et al.
patent: 6258576 (2001-07-01), Richards-Kortum et al.
Albert and Harris,Multivariate Interpretation of Clinical Laboratory Data. Marcel Dekker, New York, 1987.
Alfano et al., “Human breast tissues studied by IR fourier transform Raman spectroscopy,”Lasers in Life Sc, 4: 23-28, 1991.
Alfano et al., “Optical spectroscopic diagnosis of cancer in normal and breast tissues,”J Optic Soc Am B, 6:1015-1023, 1989.
American Cancer Society, “Cancer Facts and Figures,” 12-13, 1995.
Andersson et al., “Fluorescence imaging and point measurements of tissue: applications to the demarcation of malignant tumors and atherosclerotic lesions from normal tissue,”Photochem Photobiol, 53:807-14, 1991.
Baraga et al., “Rapid near-infrared Raman spectroscopy of human tissue with a spectrograph and CCD detector.”Appl. Spectr, 46: 187-190, 1992.
Barrasso et al., “Human papilloma viruses and cervical intraepithelial neoplasia: the role of colposcopy,”Gynecologic Oncology, 27:197-207, 1987.
Barron et al., “Statistical model of the natural history of cervical carcinoma: II. Estimates of the transition time from dysplasia to carcinoma in situ,”JNCI, 45:1025-1030, 1970.
Braichotte et al., “Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus and the bronchi,”Cancer, 75:2768-2778, 1995.
Brookner et al., “Safety analysis: relative risk of UV-fluorescence spectroscopy and endoscopy are comparable,”Photochem Photobiol, 65:1020-1025, 1997.
Burke and Ducatman,Colposcopy, text and atlas. Appleton and Large, Norwalk, CT., 1-213, 1991.
Cothren et al., “Gastrointestinal tissue diagnosis by laser induced fluorescence spectroscopy at endoscopy”.Gastrointestinal Endoscopy36:105-111, 1990.
Devore, “Probability and Statistics for Engineering and the Sciences”. Brooks/Cole, Pacific Grove, 1992.
Dillon and Goldstein,Multivariate Analysis: Methods and Applications.John Wiley and Sons, New York, 1984.
Fahey et al., “Meta-analysis of Pap test accuracy,”American J Epidemiology, 141:680-689,1995.
Farrell and Patterson, “A diffusion theory model of spatially resolved, steady-state diffus reflectance for the non invasive determination of tissue optical properties in vivo,”Medical Physic, 19:879-888, 1992.
Glassman et al., “Ultraviolet excited fluorescence spectra from non-malignant and malignant tissues of the gynecologic tract,”Lasers in Life Sciences, 5:49-58, 1992.
Gray et al., “Use of hematoporphyrin derivative in detection and management of cervical cancer,”Am J Obst&Gynec, 99:766-770, 1967.
Hung et al., “Autofluorescence of normal and malignant bronchial tissue,”Lasers in Surgery and Medicine, 11:99-105, 1991.
Kapadia et al., “Laser-induced fluorescence spectroscopy of human colonic mucosa,”Gastroenterology, 99:150-157, 1990.
Kennedy and Pottier, “Endogenous protoporphyrin IX, a clinical useful photosensitizer for photodynamic therapy,”J Photochem Photobiol B:Biol, 14:275-292, 1992.
Koss, “The Papanicolaou test for cervical cancer detection: a triumph and a tragedy,”JAMA, 261:737-743, 1989.
Kurman et al., “Interim guidelines of management of abnormal cervical cytology,”JAMA, 271:1866-1869, 1994.
Lam et al., “Detection and localization of early lung cancer by imaging techniques,”Chest, 103:12S-14S, 1993.
Lam et al., “Detection of dysplasia and carcinoma in situ by ratio fluorimetry,”Am Rev Respir Dis146:1458-1461, 1992.
Liu et al., “Raman, fluorescence and time-resolved light scattering as optical diagnostic techniques to separate diseased and normal biomedical media,”J Photochemistry and Photobiology, 16:187-209, 1992.
Loh et al., “Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy,”British Journal of Cancer,68:41-51, 1993.
Lohmann et al., “Fluorescence of the cervix uteri as a marker for dysplasia and invasive carcinoma,”European Journal of Obstetrics and Gynecology and Reproductive Biology, 131:249-253, 1989.
Mahadevan et al., “A study of the fluorescence properties of normal and neoplastic human cervical tissue,”Lasers Surg Med, 13:647-655, 1993.
Marchesini et al., “Light-induced fluorescence spectroscopy of adenomas, adenocarcinomas and non-neoplastic mucosa in human colon,”J Photochemistry and Photobiology, 14:219-230, 1992.
Mitchell, “Diagnosis and Treatment of Preinvasive Disease of the Female Lower Genital Tract”The Cancer Bulletin, 42:71-76, 1990.
Mitchell, “Accuracy of Colposcopy,”Clinical Consultations in Obstetrics and Gynecology, 6:70-73, 1994.
Montan and Stromblad, “Spectral characterization of brain tumors utilizing laser-induced fluorescence,”Lasers in Life Sciences, 1:275-285, 1987.
Ramanujam et al., “Spectroscopic diagnosis of cervical intraepithelial neoplasia (cin) in vivo using laser induced fluorescence spectra at multiple excitation wavelengths,”Lasers Surg Med, 19:63-74, 1996.
Ramanujam et al., “In vivo diagnosis of cervical intraepithelial neoplasia using 337 excitation,”PNAS, 91:10193-10197, 1994.
Rava et al., “Early detection of dysplasia in colon and bladder tissue using laser-induced fluorescence,”SPIE1426:68-78, 1991.
Reid and Scalzi, “Genital Warts and Cervical Cancer,”Am J Obstet Gynecol, 153:611-618, 1985.
Reid et al., “Genital warts and cervical cancer,”Am J Obstet Gynecol, 149:815-823, 1984.
Richards-Kortum et al., “Spectroscopic diagnosis of colonic dysplasia,”Photochem Photobiol, 53:777-786, 1991.
Schomacker et al., “Ultraviolet laser induced fluorescence of colonic tissue: basic biology and dia
Follen Michele
Mahadevan-Jansen Anita
Ramanujam Nirmala
Richards-Kortum Rebecca
Utzinger Urs
Fulbright & Jaworski L.L.P.
Smith Ruth S.
The Board of Regents of the University of Texas System
LandOfFree
Method for probabilistically classifying tissue in vitro and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for probabilistically classifying tissue in vitro and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for probabilistically classifying tissue in vitro and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3878629