Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-03-31
1987-10-20
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
047014628
ABSTRACT:
This invention provides a method for preventing the development of hypertension in a non-hypertension animal, including a human, having an elevated natriuretic hormone level, which comprises administering to said animal an amount of indoramin or a pharmaceutically acceptable salt thereof effective to lower the natriuretic hormone level.
REFERENCES:
patent: 3527761 (1970-09-01), Archibald et al.
patent: 4428954 (1984-01-01), Cavalla et al.
J. W. Woods, "Hypertension", pp. 219-223, Current Therapy 1981 (W. B. Saunders Co., 1981).
Julius and Hansson, "Classification of Hypertension," Chapt. 44, pp. 679-682, in Genest, Jacques et al., Hypertension: Physiopathology and Treatment, 2nd ed, (MacGraw-Hill Book Co., New York, 1983).
J. L. Marx, Science, 212, 1255-57 (1981).
J. L. Archibald, "Indoramin", pp. 161-177, Pharmacology of Antihypertensive Drugs A. Scriabine, ed., (Raven Press, New York, 1980).
Cross et al., Br. J. of Pharm., 81, 191P (1984).
Fairhurst et al. Br. J. of Pharm., 81, 366 P (1984).
John Wyeth and Brother Limited
Robinson Allen J.
Seifert Arthur G.
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