Method for prevention of degradation of thermally unstable...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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C514S912000, C514S913000

Reexamination Certificate

active

08030349

ABSTRACT:
The present invention provides a method for preventing the degradation of a thermally unstable medicament in an eye drop containing the medicament thereby to stabilize the eye drop. By adding an organic amine to an eye drop containing a thermally unstable medicament, the degradation of the medicament in the eye drop can be effectively prevented, and therefore the eye drop can be stably stored.

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Takagi et al., “Pharmaceutical characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug,” Experimental Eye Research, 78 (2004): pp. 767-777.
Supplementary European Search Report dated Mar. 3, 2010 for European patent application EP 06 782 153.8.

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