Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-03-15
1998-03-03
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514634, 514665, 514558, 5142388, 5142312, A61K 3752
Patent
active
057234965
ABSTRACT:
Compounds and a method useful for protection of tissue cells in a mammalian body from irreversible damages due to lactic acidosis caused by oxygen deficiency. The protection is achieved by administering a compound having a cell membrane permeability and/or ability to cross the blood brain barrier, said compound being able to provide a buffering action to prevent an increase in a hydrogen ion concentration over the physiologically acceptable levels or able to shift the intracellular pH to a more desired alkaline level.
REFERENCES:
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Frank Ashall, et al., Role of the .beta.-amyloid precursor protein in Alzheimer's disease, TIBS 19:42-45 (Jan. 1994).
Eric Growing, et al., Chemical Characterization of A.beta. 17-42 Peptide, a Component of Diffuse Amyloid Deposits of Alzheimer Disease, The Journal Of Biological Chemistry, vol. 269, No. 15, pp. 10987-10990 (Apr. 15, 1994).
Evelyne Terzi, et al., Reversible Random Coil-.beta.-Sheet Transition of the Alzheimer .beta.-Amyloid Fragment, Biochemistry, 33:1345-1350, (1994).
Debra Burdick, et al., Assembly and Aggregation Properties of Synthetic Alzheimer's A4/.beta. Amyloid Peptide Analogs, The Journal of Biological Chemistry, vol. 267, No. 1, pp. 546-554, (Jan. 5, 1992).
Colin J. Barrow, et al., Solution Structures of .beta. Peptide and Its Constituent Fragments: Relation to Amyloid Deposition, Science, 253:179-181 (1991).
Cintins Marianne M.
MacMillan Keith
The Regents of University of California
Verny Hana
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