Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1998-09-10
2000-08-01
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514170, 514171, 514177, 514178, 514179, 514180, 514181, 514182, 428451, 428464, 428489, 428490, A61K 3158, A61K 3156, A01N 4500
Patent
active
060967315
ABSTRACT:
A method for preventing tissue damage associated with graft-versus-host disease in a patient having undergone hematopoietic cell transplantation, and host-versus-graft disease in a patient having undergone organ allograft transplantation. The method includes orally administering to the patient a prophylactically effective amount of a topically active corticosteroid, such as beclomethasone dipropionate, for a period of time following hematopoietic cell or organ allograft transplantation, and prior to the presentation of symptoms associated with graft-versus-host disease or host-versus-graft disease. Representative tissues includes tissue of the intestine and liver, while representative tissue damage includes inflammation thereof.
REFERENCES:
patent: 5403833 (1995-04-01), Calne
"Oral Beclomethasone Diproprionate for Treatment of Human Intestinal Graft-Versus Host Disease", Baehr et al, Transplantation 60:1231-1238, Apr. 1995.
"Graft-Versus-Host Effect After Allogenic Hematopoietic Stem Cell Transplantation: GVHD and GVL", Nash et al, Curr. Opin. Immunol., 8(5), 674-680, Mar. 1996.
Institute for Drug Research, Inc.
Krass Frederick
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