Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-11-05
2000-05-09
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514254, 6048911, A61K 31495, A61K 922
Patent
active
060604743
ABSTRACT:
Disclosed herein are methods for reducing or preventing scar tissue formation by administering an antifibrotic amount of a fluoroquinolone. Also disclosed are means for inhibiting the activity of fibroblast cells, including their proliferation, metabolism, and invasion into tissue. The invention further contemplates methods and compositions for the delivery of a fluoroquinolone to prevent or treat scar tissue formation, including oral and intravenous delivery means.
REFERENCES:
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Movin et al., Pathology of Achilles Tendon in Association with Ciprofloxacin Treatment, Foot & Ankle International, 18, 297-99 (1997).
Moreira et al., Effect of Topical Fluoroquinolones on Corneal Re-Epithelialization After Excimer Laser Keratectomy, J. Cataract Refract. Surg. 23, 845-48 (1997).
McGarvey et al., Partial Achilles Tendon Ruptures Associated with Fluoroquinolone Antibiotics: A Case Report and Literature Review, Foot & Ankle International 17, 496-98 (1996).
Zabraniecki et al., Fluoroquinolone Induced Tendinopathy: Report of 6 Cases, J. Rheumatol. 23, 516-20 (1996).
Szarfman et al., More on Fluoroquinolone Antibiotics and Tendon Rupture, N. Eng. J. Med., 332, 193 (1995).
MacGowan et al., Serum Ciprofloxacin Concentrations in Patients with Severe Sepsis Being Treated with Ciprofloxacin 200 MG IV BD Irrespective of Renal Function, Journal of Antimicrobial Chemotherapy, 33, 1051-54 (1994).
Royer et al., Features of Tendon Disorders with Fluoroquinolones, Therapie 49, 75-76 (1994).
Shah et al., Comparative Pharmocokinetics and Safety of Ciprofloxacin 400 MG IV Thrice Daily Versus 750 MG PO Twice Daily, Journal of Antimicrobial Chemotherapy, 33, 795-801 (1994).
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Hannafin Jo A.
Williams Riley J.
New York Society for the Relief of the Ruptured and Crippled Mai
Peselev Elli
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