Method for preventing or treating depression employing a combina

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 7, 514 89, 514 91, 514 92, 514 94, 514171, 514212, 514218, 5142235, 514249, 514255, 514278, 514318, 514338, 514343, 514409, 514422, 514423, 514616, 514693, A61K 3140, A61K 31675, A61K 3702

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active

050325787

ABSTRACT:
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a drug that acts at serotonin receptors such as zacopride, over a prolonged period of treatment.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4311697 (1982-01-01), Krapcho
patent: 4311705 (1982-01-01), Ondetti et al.
patent: 4316906 (1982-02-01), Ondetti et al.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4379146 (1983-04-01), Greenlee et al.
patent: 4381297 (1983-04-01), Karanewsky et al.
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4602002 (1986-07-01), Patchett et al.
patent: 4912096 (1990-03-01), Sudilovsky
patent: 4931430 (1990-06-01), Sudilovsky et al.
Costall et al (1989), "The Effects of ACE Inhibitors Captopril and SO29,852 in Rodent Tests of Cognition," Pharmacol. Biochem. Behav. 33; 573-579.
Barnes, J. M. et al (1990), "The Effects of Ondansetron, 5-HT.sub.3 Receptor Antagonist, on Cognition in Rodents and Primates," Pharmacol. Biochem. Behav. (35; 955-961.
Sudilovsky et al, "Captopril Delays Extinction of Conditional Avoidance Response in the Rat," Poster Presentation, 14th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Florence, Italy, Jun. 1984.
"Angiotensin Converting Enzyme Inhibitors: Animal Experiments Suggest a New Pharmacological Treatment for Alcohol Abuse in Human," G. Spinosa et al, Alcoholism: Clinical and Experimental Research, vol. 12, No. 1, Jan./Feb. 1988, pp. 65-70.
"Alcohol Satiety, Hypertension and the Renin-Angiotensis System," L. A. Grupp, Medical Hypotheses (1987) 24, 11-19 (Longman Group UK Ltd 1987).
Melo, J. C. et al, J. Pharmacol., 193:1-9 (1975).
Morgan, J. M. et al, Science, 196:87-89 (1977).
Koller, M. et al, Neuroscience Letters, 14:71-75 (1979).
Evered, M. D., Europ. J. Pharmacol., 68:443-449 (1980).
Marson, O. et al, Brazil. J. Med. Biol. Res., 14:73-76 (1981).
Arregui, A. et al, J. Neurochem., 103:1490-1492 (1982).
Scholkens, B. A. et al, Clin. Exper. Hyper.-Theor. Pract., A5:1301-1317 (1983).
Mann, J. F. E. et al, Clin. Sci., 56:585-589 (1979).
Vollmer R. R. et al, Europ. J. Pharmacol., 45:117-125 (1977).
Croog et al, "The Effects of Antihypertensive Therapy on the Quality of Life," New England Journal of Medicine, 314:1657-1664 (Jun. 26), 1986.
Sudilovsky et al, "The Effects of Zofenopril, Captopril and Methyldopa on Shuttle Avoidance Response Extinction in Rats," Poster Presentation, 15th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, San Jaun, Puerto Rico, Dec. 1986.
Sudilovsky et al, "Differential Effects of Captopril, Methyldopa and Propranolol on Cognitive Functioning of Hypertensive Patients," Poster Presentation, 25th Annual Meeting of the American College of Neuropsychopharmacology, Wash., D.C., Dec. '86.
Deicken, R. F., "Captopril Treatment of Depression," Biol. Psychiatry, 1986; 21:1425-1428.
Zubenko, G. S., "Mood-Elevating Effect of Captopril in Depressed Patients," Am. J. Psychiatry, 141:110-11, 1984.
Germain, L. et al, "Treatment of Recurrent Unipolar Major Depression with Captopril," Biol. Psychiatry, 1988; 23:637-641.
Giardina, W. J. et al, "Positive Effects of Captopril in the Behavioral Despair Swim Test," Biol. Psychiatry, 1989; 25:695-702.
Bosio, A. et al, "Antidepressant Activity of ACE-Inhibitors," TIPS, vol. 8, pp. 329-330, 1987 (Abstracts of 141st Annual Meeting of the American Psychiatric Association, Montreal, Canada, May 7-12, 1988.
Buspirone (PDR, 1990, p. 1308).

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