Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-01-09
1998-05-12
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514821, A61K 3800
Patent
active
057505071
ABSTRACT:
The present invention provides a preventive or therapeutic agent for tissue injury caused by active oxygens and free radicals, having for its effective component .gamma.-L-glutamyl-L-cysteine ester derivative indicated in the following general formula: ##STR1## wherein, R is a straight chain, branched or cyclical hydrocarbon group having 1-10 carbon atoms, or a straight chain or branched hydrocarbon group having 1-5 carbons substituted with an aromatic group, or its oxidized dimer
This compound has the effect of elevating glutathione levels in tissue and biochemically substitute for glutathione thereby performing preventive or therapeutic effects against ischemia-reperfusion tissue injury in the heart, liver and other organs, arrhythmia, as well as lung injury caused by active oxygens and free radicals.
REFERENCES:
patent: 4927808 (1990-05-01), Kitahara et al.
Nishinaka et al., The Cardioprotective Effect of .gamma.Glutamylcysteine Ethyl During Coronary Reperfusion in Canine Hearts, British Journal of Pharmacologo, vol. 104, No. 4, pp. 805-810, Dec. 1991.
Ohtsu et al., "Anticataractogenic Property of .gamma.-Glutamylcysteine Ethyl Ester in an Animal Model of Cataract," Ophthalmic Research, vol. 23, No. 1, pp. 51-58, Jan. 1991.
Singh et al., "Relation Between Myocardial Glutathione Content and Extent of Ischemia-Reperfusion Injury," Circulation, vol. 80, No. 6, pp. 1795-1804, 1989.
Stein et al., "Oxygen Free Radicals and Glutahione in Hepatic Ischemia/Reperfusion Injury," Journal of Surgical Research, vol. 50, No. 4, pp. 398-402, Apr. 1991.
Marubayashi et al., "Changes in the Levels of Endogenous Coenzyme Q Homologs, .alpha.-Tocopherol, and Glutathione in Rat Liver After Hepatic Ischemia and Reperfusion, and the Effect of Pretreatment with Coenzyme Q.sub.10," Biochemica et Biophysica Acta, vol. 797, No. 1, pp. 1-9, Jan. 24, 1984.
Woodward et al., "Effect of Some Free Radical Scavengers on Reperfusion Induced Arrhythmias in the Isolated Rat Heart," J. Mol. Cell. Cardiol., vol. 17, No. 5, pp. 485-493, 1985.
Lackson et al., "Effects of Hypoxia (Ischemia) and Re-Oxygenation (Reperfusion) on Lung Glutathione System," American Review of Respiratory Disease, vol. 139, No. 4, p. A39, Apr. 1989.
Flohe et al., The Identity of Glutathione Peroxidase from Erythrocytes and Liver (Contraction Factor I) of the Rat, Journal of Clinical Chemistry and Clinical Biochemistry, Mar. 1970.
Pschyrembel, 256 ed., 1990, p. 1142 "Nekrose".
Kobayashi et al., "The Effects of .gamma.-Glutamylcysteine Ethyl Ester, a Prodrug of Glutathione, on Ischemia-Reperfusion-Induced Liver, Injury in Rats," Transplantation, vol. 54, No. 3, pp. 414-418, Sep. 1992.
Ikuta et al., "Implication of Oxygen Radicals on Airway Hyperesponsiveness After Ovalbumin Challenge in Guinea Pigs," American Review of Respiratory Disease, vol. 145, No. 3, pp. 561-565, Mar. 1992.
Journal of Neurochemistry, vol. 34, p. 477-486, 1980.
Circulation, vol. 81, pp. 201-211, 1990.
Lung, vol. 169, pp. 123-138, 1991.
Current Surgery, Jan./Feb. 1988 Issue, pp. 31-33.
YiMin et al., "Various Disease Caused by Free Radical," Contemporary Medicine Journal, vol. 18, period 5, pp. 54-62, Extract, Republic of China, May 15, 1989.
Blaustein et al., "Protective Effects of Glutathione on Ventricular Compliance and Coronary Resistance During Ischemia/Reperfusion," FASEB, vol. 3, No. 3, p. A627, Mar. 1989.
Fujii Katsuhiko
Kitahara Shigehisa
Ozawa Takayuki
Sugiyama Satoru
Jordan Kimberly
Teijin Limited
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