Method for preventing or treating a lung disease caused by activ

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514826, A61K 3800

Patent

active

061273422

ABSTRACT:
The present invention provides a preventive or therapeutic agent for tissue injury caused by active oxygens and free radicals, having for its effective component .gamma.-L-glutamyl-L-cysteine ester derivative indicated in the following general formula: ##STR1## wherein, R is a straight chain, branched or cyclical hydrocarbon group having 1-10 carbon atoms, or a straight chain or branched hydrocarbon group having 1-carbons substituted with an aromatic group, or its oxidized dimer.
This compound has the effect of elevating glutathione levels in tissue and biochemically substitute for glutathione thereby performing preventive or therapeutic effects against ischemia-reperfusion tissue injury in the heart, liver and other organs, arrhythmia, as well as lung injury caused by active oxygens and free radicals.

REFERENCES:
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Ohtsu et al., "Anticataractogenic Property of .gamma.-Glutamylcysteine Ethyl Ester in an Animal Model of Cataract," Ophthalmic Research, vol. 23, No. 1, pp. 51-58, Jan. 1991.
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