Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-10-16
2000-10-03
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514826, A61K 3800
Patent
active
061273422
ABSTRACT:
The present invention provides a preventive or therapeutic agent for tissue injury caused by active oxygens and free radicals, having for its effective component .gamma.-L-glutamyl-L-cysteine ester derivative indicated in the following general formula: ##STR1## wherein, R is a straight chain, branched or cyclical hydrocarbon group having 1-10 carbon atoms, or a straight chain or branched hydrocarbon group having 1-carbons substituted with an aromatic group, or its oxidized dimer.
This compound has the effect of elevating glutathione levels in tissue and biochemically substitute for glutathione thereby performing preventive or therapeutic effects against ischemia-reperfusion tissue injury in the heart, liver and other organs, arrhythmia, as well as lung injury caused by active oxygens and free radicals.
REFERENCES:
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Fujii Katsuhiko
Kitahara Shigehisa
Ozawa Takayuki
Sugiyama Satoru
Jordan Kimberly
Teijin Limited
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