Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-01-28
1997-09-16
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31395
Patent
active
056681348
ABSTRACT:
The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a photosensitivity and/or phototoxicity reaction in a patient comprising administering the prescribed or suggested dose of the medication to the patient during the evening or early morning hours.
The present invention also provides an article of manufacture comprising: (1) a packaging material, and (2) a once-a-day dose medication which causes a photosensitivity and/or a phototoxicity reaction in a patient contained within said packaging material, wherein such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and wherein said packaging material comprises a label which indicates that such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and/or that such medication is to be administered during the evening or early morning hours, and/or wherein the packaging material is arranged in a manner which releases the medication to the patient during the evening or early morning hours.
REFERENCES:
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Kiyoshi Marutani, et al. "Reduced Phototoxicity of a Fluoroquinolone Antibacterial Agent with a Methoxy Group at the 8 Position in Mice Irradiated with Long-Wavelength UV Light", Antimicrobial Agents and Chemotherapy, vol. 37, No. 10, pp. 2217-2223, (1993).
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Keiichi Tozawa, et al. "A Clinical Study of Lomefloxacin on Patients with Urinary Tract Infections. Focused on Lomefloxacin-induced photosensitivity reaction", Acta Urol. Jpn., vol. 39, pp. 801-805, (1993) *(English translation of Japanese article is attached).
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Klimstra Paul Dale
Roniker Barbara
Swabb Edward Allen
G. D. Searle & Co.
Hastreiter Roberta L.
Reamer James H.
Williams Roger A.
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