Method for preventing onset of restenosis after angioplasty empl

Details Method for preventing onset of restenosis after angioplasty empl Method for preventing onset of restenosis after angioplasty empl

1990-05-31

1992-08-18

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 89, 514 91, 514 92, 514 94, 514171, 514212, 514218, 5142235, 514249, 514255, 514278, 514318, 514338, 514343, 514409, 514422, 514423, 514533, 514616, 514693, A61K 3702, C07K 506

Patent

active

051400120

ABSTRACT:
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or ceranapril, prior to, during and/or after angioplasty.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
Gellman, J. et al., "Lovastatin, a HMG CoA Reductase Inhibitor, Reduces Restenosis Following Balloon Angioplasty in an Atherosclerotic Hypercholesterolemic Rabbit", Clinical Research, vol. 37, No. 2, 1989, p. 261A.
Clin. Res. 36, 1988: 259A.
Clin. Invest 83, 1985: 1419.
Clin. Res. 37, 1989: 286A.
Sahni, R. et al., "Prevention of Restenosis by Lovastatin", 62nd Scientific Sessions of the American Heart Assoc., New Orleans, Nov. 13-16, 1989, Circulation 80 (4 Suppl. 2) 1989, p. II-65.
Gellman, J. et al., "Lovastatin, a HMG CoA Reductase Inhibitor, Reduces Restenosis Following Balloon Angioplasty in an Atherosclerotic Hypercholesterolemic Rabbit", Clinical Research, vol. 37, No. 2, 1989, p. 261A.
Powell, J. S. et al., "Inhibitors of Angiotension-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury", Science, vol. 245, 186-188, Jul. 14, 1989.
Chobanian, A. V. et al., "Antiatherogenic Effect of Captopril in the Watanabe Heritable Hyperlipidemic Rabbit", Hypertension, vol. 15, No. 3, Mar. 1990, pp. 327-331.

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