Method for preventing onset of restenosis after angioplasty empl

Details Method for preventing onset of restenosis after angioplasty empl Method for preventing onset of restenosis after angioplasty empl

1991-06-13

1992-11-24

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 76, A61K 31675

Patent

active

051661438

ABSTRACT:
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.

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Powell, J. S., et al., "Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury", Science, vol. 245, pp. 186-188, Jul. 14, 1989.
"AII is MItogenic for Endothelial Cells", Clin. Res., 36, 1988:259A; April, 1988.
"Exposure of Smooth Muscle Cells to AII Results in Expression of the Proto-Oncogene for PDGF", J. Clin. Invest., 83, April 1989:1419.
"Cilazapril (and Captopril) Reduces the Myointimal Proliferation (Restenosis) in Rat Carotids Subjected to Balloon ANgioplasty", Clin. Res., 37, April 1989:286A.

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