Method for preventing onset of hypertension employing a choleste

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 91, 514356, 514423, 514543, 514545, 514548, 514567, 514571, 514712, 514741, A61K 3170, A61K 31675, A61K 3144, A61K 3140, A61K 3104, A61K 31235, A61K 31225, A61K 31195, A61K 3119, A61K 3110

Patent

active

055939716

ABSTRACT:
A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.

REFERENCES:
patent: 4871721 (1989-06-01), Biller
patent: 4924024 (1990-05-01), Biller
patent: 5298497 (1994-03-01), Tschollar et al.
patent: 5461039 (1995-10-01), Tschollar et al.
Olefsky et al, "Insulin Action and Resistance in obesity and non-insulin dependent type II diabetes mellitus," Am. J. Physiol. 1982; 243:E15-330.
Stout, R. W., "Insulin and atheroma--an update," Lancet 1987, I:1077-1079.
Ferrannini et al, "Insulin resistance in essential hypertension," N. engl. J. Med. 1987, 217:350-357.
Modan et al, "Hyperinsulinemia--alink between glucose intolerance, obesity, hypertension, dyslipoproteinaemia, elevated serum uric acid and internal kation imbalance," Diab. Met. 1987, 13:375-380.
Skarfors et al, "Do antihypertensive drugs precipitate diabetes in predisposed man?" Br. Med. J. 1989, 298: 1147-1152.
Pollare et al, "Insulin Resistance is a Characteristic Feature of Primary Hypertension Independent of Obesity," Metabolism, vol. 39, No. 2 (Feb.), 1990, pp. 167-174.
Pollare et al, "A comparison of the effects of Hydrochlorothiazide and Captopril on Glucose and Lipid metabolism in Patients with Hypertension," New England Journal of Medicine, 321:868-873 (Sep. 28) 1989.
Rett et al, "Angiotensin converting enzyme inhibitors in diabetes: Experimental and human experience," Postgrad. Med. J. (U.K.), 1986 62/Suppl. 1 (59-64).
Jauch et al, "Captopril enhances insulin responsiveness of forearm muxcle tissue in non-insulin-dependent diabetes mellitus," Eur. J. Clin. Invest. (U.K.), 1987, 17 May (448-454).
Edelman et al, "Hyperkalemia During Treatment with HMG CoA Reductase Inhibitor," N. Engl. J. Med. (320, No. 18, 1219-20, 1989).
Zorn et al, "Prevention of Arteriosclerotic Lesions with Calcium Antagonists or Captopril in Different Rat Hypertension Models," J. Cardiovasc. Pharmacol. vol. 12 (Suppl. 6), 1988.
Someya et al, "Suppressive Effect of Captopril on Platelet Aggregation in Essential Hypertension," J. Cardiovasc. Pharmacol. 6:840-843, 1984.
Mizuno et al, "The effects of the angiotensin I-converting enzyme inhibitor, captopril, on serum lipoperoxides level and the renin-angiotensin-aldosterone and kallikrein-kinin systems in hypertensive patients," Nippon Naibunpi Gakkai Zasshi, Feb. 20, 1984.
Mizuno et al, "Acute effects of captopril on serum lipid peroxides level in hypertensive patients," Tohoku J. Exp. Med., May, 1984, 143(1) pp. 127-128.
Beisterfer et al, "Angiotensin II Induces Hypertrophy, not Hyperplasia, of Cultured Rat Aortic Smooth Muscle Cells," Circ. Res. 62:749-756, (1988).
Overturf et al, "Hypertension and Atherosclerosis in Cholesterol-Fed Rabbits Part 1. Mild, Two-Kidney, One-Clip Goldblatt Hypertension treated with Enalapril," Atherosclerosi 59:283-299, 1986.
Cecil, Textbook of Medicine, 16 Ed., pp. 239-241 (1983).
McClard et al, "Novel Phosphonylphosphinyl (P--C--P--C--) Analogue of Biochemically Interesting Diphosphates. Syntheses and Properties of P--C--P--C-- Analogues of Isopentenyl Diphosphate an Dimethylallyl Diphosphate," J.A.C.S. 1987, 109, 5544-5545.
Biller et al, "Isoprenoid (Phosphinylmethyl) phosphonates as Inhibitors of Squalene Synthetase," Journal of Medicinal Chemistry, 1988, vol. 31, No. 10, pp. 1869-1871.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for preventing onset of hypertension employing a choleste does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preventing onset of hypertension employing a choleste, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preventing onset of hypertension employing a choleste will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1388233

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.