Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1996-06-05
1998-03-17
Krass, Frederick
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
424 7804, 424428, 514 54, 514 57, 514 59, 514 62, 604294, 604295, 604301, 6048901, A61K 3174, A61K 900
Patent
active
057284059
ABSTRACT:
Keratocyte loss after trauma or injury to the corneal epithelium is prevented or reduced by applying to the corneal epithelium a keratocyte maintenance solution over a period of time sufficient to permit corneal wound healing. The keratocyte maintenance solution is applied to the cornea after trauma (for example, removal of the epithelium prior to surgery, such as photorefractive keratectomy). Preferably, the solution is maintained over the cornea by means of a fluid bath or by means of an absorbent material effective for controlled release of the solution to the cornea (e.g., a collagen shield substantially in the form of a conventional contact lens). A preferred keratocyte maintenance solution is a corneal storage medium.
REFERENCES:
patent: 3843782 (1974-10-01), Krezanoski et al.
patent: 4443432 (1984-04-01), Garabedian et al.
patent: 4581226 (1986-04-01), Dillon
patent: 4695536 (1987-09-01), Lindstrom et al.
patent: 4837021 (1989-06-01), Andermann et al.
patent: 4886786 (1989-12-01), Lindstrom et al.
patent: 4946450 (1990-08-01), Erwin
patent: 5104787 (1992-04-01), Lindstrom et al.
patent: 5143731 (1992-09-01), Viegas et al.
patent: 5242902 (1993-09-01), Murphy et al.
patent: 5277911 (1994-01-01), Viegas et al.
patent: 5318780 (1994-06-01), Viegas et al.
patent: 5380537 (1995-01-01), Andermann
Dohlman, C.H., "The function of the corneal epithelium in health and disease. The Jonas S. Friedenwald Memorial Lecture," Invest. Ophthalmol., vol. 10, No. 6, 383-407 (1971).
Dohlman, C.H. et al., "The effect of the absence of corneal epithelium or endothelium on the stromal keratocytes," Invest. Ophthalmol., vol. 7, No. 5, 520-534 (1968).
Fantes, F. et al., "Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys," Arch. Ophthalmol., vol. 108, 665-675 (1990).
Hirst, L.W. et al., "Comparative studies of corneal surface injury in the monkey and rabbit," Arch. Ophthalmol., vol. 99, 1066-1073 (1981).
Kaufman, H.E. et al., "Optisol Corneal Storage Medium," Arch. Ophthalmol., vol. 109, 864-868 (1991).
Kenyon, K.R. et al., "Prevention of stromal ulceration in the alkali-burned rabbit cornea by glued-on contact lenses. Evidence for the role of polymorphonuclear leukocytes in collagen degradation," Invest. Ophthalmol. Vis. Sci., vol. 18, No. 6, 570-587 (1979).
Lindstrom, R.L. et al., "Optisol Corneal Storage Medium," Am. J. Ophthalmol., 114, 345-356 (1992).
McDonald, M.B. et al., "One-year refractive results of central photorefractive keratectomy for myopia in the nonhuman primate cornea," Arch. Ophthalmol., vol. 108, 40-47 (1990).
Nakayasu, K., "Stromal changes following removal of epithelium in rat cornea," Jpn. J. Ophthalmol., vol. 32:113-125 (1988).
Saika, S., "Ultrastructural effect of L-ascorbic acid 2-phosphate on cultured keratocytes," Cornea 11(5):439-445 (1992).
Hermann, Heinz et al., "ATP Level, Cell Injury, and Apparent Epithelium-Stroma Interaction in the Cornea", J. Cell Biol., 25:465-71 (1962).
Johnson-Muller et al., "Regulation of Corneal Collagenase Production: Epithelial-stromal Cell Interactions", Proc. Natl. Acad. Sci., 75:4417-4421 (1978).
Chemical Abstracts 106:169003, "The Effect Of a New Intraocular Irrigating Solution Containing Dextran on Rabbit Corneal Epithelium", Polack et al., Apr. 1986.
Medline Abstracts 89036717, "Clinical Uses of Collagen Shields", Poland et al., Sep. 1988.
Krass Frederick
University of Southern California
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