Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1994-06-02
1997-10-21
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241451, 53038825, 5303893, 530350, 530380, 530395, 514 8, 514 12, C07K 1618, C07K 14435, A61K 39395, A61K 3817
Patent
active
056793456
ABSTRACT:
Interference with formation of the complement-based membrane attack complex (MAC) will mitigate or even prevent tissue injury associated with the effects of complement in inflammation and graft rejection. Passive treatment of xenograft recipients at the time of and after transplantation with antibody against C-6, which interrupts the sequence of binding steps that form MAC, has been observed to suppress hyperacute xenograft rejection with no adverse signs or symptoms in the xenograft recipient. The present invention provides a method for interfering with MAC formation in transplant recipients, by administering compounds which interrupt one or more of the binding reactions between C5b and C6-C9, so that the MAC cannot form.
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Baldwin, III William M.
Brauer Robert B.
Sanfilippo Alfred P.
Eisenschenk Frank C.
The Johns Hopkins University
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