Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...
Patent
1993-12-02
1995-08-08
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving fixed or stabilized, nonliving microorganism,...
424 75, 435 1, 435 2, 435 4052, A01N 102
Patent
active
054396670
ABSTRACT:
Methods are provided to prepare a variety of tissues in a pathology-stable form for microscopic examination by preserving the tissue with an aqueous solution of C.sub.2-6 dialdehyde and/or dialdehyde addition products, including glyoxal and/or glutaraldehyde in an amount sufficient to prevent autolysis and other degradative changes. The solution may further contain alcohols, chelating agents, buffers and acids. In one embodiment,-the aqueous solution contains glyoxal or glyoxal in the form of a bisulfite, hydrate or alcohol addition product and an osmotic controlling ionic and/or nonionic chemical. This solution prevents degradation of tissue without substantial cross-linking.
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Yanoff et al. "Glutaraldehyde Fixation of Whole Eyes," The American Journ. of Clin Pathology . vol. 44(2), 1965 . pp. 167-171.
Lankford L. Blaine
Naff David M.
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