Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1991-07-08
1993-06-08
Naff, David M.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
435283, A01N 102
Patent
active
052178609
ABSTRACT:
A computer-controlled apparatus and method for perfusing a biological organ, such as a heart, kidney, liver, etc. The apparatus comprises a plurality of fluid reservoirs and an organ container for holding the biological organ. A first fluid flow path is defined as a loop from the plurality of reservoirs to necessary sensors and temperature conditioning means and back to the plurality of reservoirs. The reservoirs are selectively connectable to the first fluid flow path. Pump means are interposed in the first fluid flow path for pumping fluid from the first fluid flow path to a second fluid flow path. The organ container is located in this second fluid flow path. Pump means may also be included in the second fluid flow path for pumping fluid from the organ container to one or more of the reservoirs or to waste. One or more sensors are interposed in the fluid flow paths for sensing at least one of the concentration, temperature, pH, and pressure of the fluid flowing in the first and second fluid flow paths. Measuring means are interposed in the first and second fluid flow paths for measuring concentration and temperature differences between the upstream and downstream sides, in the fluid flow direction, of the organ container. The sensor(s) and the measuring means are connected to a programmable computer for providing a continuous information stream from the sensor(s) to the computer. The computer is coupled to the selection means and the pump means to continuously selectively control (a) the flow of fluid from each of the reservoirs individually to the fluid flow paths, and (b) at least one of the concentration, temperature, pressure and pH of the fluid flowing in the second fluid flow path, in accordance with a predetermined computer program without operator intervention.
REFERENCES:
patent: 3753865 (1973-08-01), Belzer et al.
patent: 3772153 (1973-11-01), De Roissart
patent: 3843455 (1974-11-01), Bier
patent: 3892628 (1975-07-01), Thorne et al.
patent: 3914954 (1975-11-01), Doerig
patent: 3995444 (1976-12-01), Clark et al.
patent: 4559298 (1985-12-01), Fahy
patent: 4618586 (1986-11-01), Walker
patent: 4629686 (1986-12-01), Gruenberg
patent: 4798824 (1989-01-01), Belzer et al.
patent: 4837390 (1989-06-01), Reneau
patent: 4879283 (1989-11-01), Belzer et al.
Armitage W. J., Cryobiology 26:318-27 (1989).
Rebmann U. et al, Z. Urol. Naphrol. 78:611-17 (1985) Abstract.
Becker K. et al, Biomed Biochim Acta 47:S117-120 (1989).
Hooper T. L., et al, Transplantation 49:495-9 (1990).
Adem et al., J. Biomed. Engng. 3:134-139 (1981).
Armitage et al., Cryobiology 18:370-377 (1981).
Belzer et al., Organ Perfusion and Preservation (J. C. Norman et al., editors), Appleton-Century-Crofts, New York, 1968, pp. 3-12.
Fahy, G. M., Cryo-Letters 1:312-317 (1980).
Fahy et al., Cryo-Letters 5:33-46 (1984).
Fahy et al., Cryobiology 21:407-426 (1984).
Fahy et al., Cryobiology 22:607-608 (1985).
Jacobsen et al., Cryobiology 15:18-26 (1978).
Jacobsen, IB A., Cryobiology 15:302-311 (1978).
Pegg, D. E., Cryobiology 9:411-419 (1972).
Pegg et al., Cryobiology 14:168-178 (1977).
Pegg, D. E., Banking of Cells, Tissues and Organs at Low Temperatures. In: Current Trends in Cryobiology (A. U. Smith, editor), Plenum Press, NY, 1970, pp. 153-180, but particularly pp. 175-177.
Perry, R. M., Cryonics 9:24-38 (1988).
Sadri, F., Organ Perfusion Systems: An Evaluation Criteria, T.O.P.S. Medical Corp. (1987).
Sherwood et al., Organ Preservation, Chap. 15, pp. 152-174.
Water Instruments Medical Group, Waters Instrument Inc., Price List, 1982.
Fahy Gregory M.
Khirabadi Bijan S.
Naff David M.
Saucier S.
The American National Red Cross
LandOfFree
Method for preserving organs for transplantation by vitrificatio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for preserving organs for transplantation by vitrificatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preserving organs for transplantation by vitrificatio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1933221