Method for preserving liposomes

Details Method for preserving liposomes Method for preserving liposomes

1987-05-21

1989-08-15

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

424 944, 514 2, 514 3, 514 76, 514 77, 514 78, 514 44, 514579, 514646, 435 4, 435 26, 436829, A61K 3724, A61K 3748

Patent

active

048573191

ABSTRACT:
A method for preserving liposomes includes freeze-drying liposomes most preferably having an average size of about 50 nm to 100 nm with a disaccharide preserving agent being present both internally (with the encapsulated liposomal contents) and externally. The disaccharide component is in a weight ratio with respect to the lipid component of from at least about 0.1:1 to not greater than about 4:1 and is preferably trehalose. When the lyophilizates are reconstituted by rehydration, the resultant liposomes can retain up to 100% of the originally encapsulated contents.

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