Method for preserving a liver by perfusion with or storage in a

Details Method for preserving a liver by perfusion with or storage in a Method for preserving a liver by perfusion with or storage in a

1995-06-13

1997-08-26

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

514100, 549220, A01N 102, A61K 31665

Patent

active

056609760

ABSTRACT:
This invention provides a hepatic graft preservative composition containing a phosphoric acid diester compound of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof and a method for viable preservation of the hepatic graft using the above substance.
The hepatic graft preservative composition and hepatic graft preserving method of this invention inhibit hepatic microcirculation disturbance following cold storage-reperfusion of the liver to effectively prevent necrosis of hepatocytes and is, therefore, useful for the preservation of the hepatic graft.

REFERENCES:
patent: 4948786 (1990-08-01), Shimamoto et al.
patent: 5145771 (1992-09-01), Lemasters et al.
patent: 5306713 (1994-04-01), Suetsugu et al.
patent: 5480773 (1996-01-01), Ogata et al.
Obata, Chemical Abstracts, vol. 118, No. 1 4 Jan. 1993, Columbus, Ohio U. S. Abstract No. 4606.
Tanemoto et al., Chemical Abstracts, vol. 119, No. 5, 2 Aug., 1993, Columbus, Ohio U.S. Abstract No. 40876.
Takayama et al., Chemical Abstracts, vol. 120, No. 7, 14 Feb. 1994, Columbus, Ohio U.S. Abstract No. 74626.
Tanemoto et al., Acta. Med. Okayama, 47(2) pp. 121-127 (1993).

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