Method for preparing zinc interferon alpha-2 crystals

Details Method for preparing zinc interferon alpha-2 crystals Method for preparing zinc interferon alpha-2 crystals

1995-06-06

1998-04-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

530351, A61K 3819, C07K 1452

Patent

active

057414858

ABSTRACT:
A method for making crystals of zinc interferon alpha-2, and the use thereof in depot formulations, are disclosed.

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T.L. Nagabhushan et al, Interferon: Research, Clinical Application & Regulatory Consideration, pp. 79-88. (1982). David L. Miller, et al. Science 215, pp. 689-690, 5 Feb. 1982.
David L. Miller, et al. Science 215, pp. 689-690, 5 Feb. 1982.
C. Weissmann, et al., Structure and expression of human IFN-a genes Phil. Trans. R. Soc. Lond. B299, 7-28 (1982).
Alexander McPherson, Preparation and Analysis of Protein Crystals. John Wiley & Sons, pp. 102-104. (1982).
Sydney Pestka, et al. Interferons and Their Actions. Ann. Rev. B iochem. 1987. 56:727-77.
Michael Steuli, et al, At Least Three Human Type a Interferons: Structure of a2., Science 209, 19 Sep. 1980.
Senadhi Vijay-Kumar, et al. Crystallization and Preliminary X-ray Investigation of a Recombinant From of Human .alpha.-Interferon, pp. 4804-4805, (1987).
K. Henco, et al. Structure Relationship of Human Interferon Alpha Genes and Pseudogenes, J. Mol. Bio. (1985) 185, 227-260.
Interferon Y Biotechnologia vol. 5, No. 3 Sep. 1988, Havana-Cuba pp. 281-287, A. Diaz: La Cristalizacion del Interferon Alpha-2 Recombinante Humano.

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