Method for preparing urokinase injection

Details Method for preparing urokinase injection Method for preparing urokinase injection

1979-05-09

1981-01-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424177, 435188, 435215, A61K 3748, A61K 3700, C12N 996, C12N 972

Patent

active

042449430

ABSTRACT:
A method for preparing a stable urokinase injection by the liophilization of urokinase which comprises liophilizing an aqueous solution containing urokinase, human serum albumin and one or more amino acid compounds selected from polar amino acids and salt thereof. The urokinase injection obtained according to this method is excellent in the storing stability as compared with conventional urokinase preparations for injection.

REFERENCES:
Miyata et al., Chem. Abst., vol. 88, (1978), p. 18304d.
Yukari et al., Chem. Abst., vol. 82, (1975), p. 27955v.

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