Method for preparing two-layer bicomposite collagen material...

Details Method for preparing two-layer bicomposite collagen material... Method for preparing two-layer bicomposite collagen material...

2006-07-11

2006-07-11

Naff, David M. (Department: 1651)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C424S093700, C424S426000, C435S177000, C435S395000, C530S356000, C530S402000

Reissue Patent

active

RE039172

ABSTRACT:
A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 μm to less than 100 μm thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 μm to 300 μm and a thickness of 0.2 cm to 1.5 cm.

REFERENCES:
patent: 5201745 (1993-04-01), Tayot et al.
patent: 6391939 (2002-05-01), Tayot et al.
patent: WO 93/10731 (1993-06-01), None
patent: WO 98/34656 (1998-08-01), None

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