Method for preparing time-stable solutions of non-pyrogenic magn

Details Method for preparing time-stable solutions of non-pyrogenic magn Method for preparing time-stable solutions of non-pyrogenic magn

1989-01-06

1990-10-09

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514968, C07D31300

Patent

active

049622080

ABSTRACT:
A method is improved for producing highly stable non-pyrogenic solutions of magnesium gluconocitrate. According to this process a specially prepared non-pyrogenic magnesium hydroxycarbonate or magnesium carbonate, gluconic acid anhydride and citric acid are first admixed to form a powder. The admixed powder is then added to an aqueous medium and heated to a temperature of at least about 80.degree. C. to rapidly drive out substantially all of the carbon dioxide. Alternatively, the aqueous medium may be heated to a temperature of at least 80.degree. C. prior to the addition of the powder. The magnesium hydroxycarbonate or magnesium carbonate is prepared by heating to 165.degree. C. for about 18 hours in thin layers in the presence of steam and an oxidizing atmosphere whereby any and all traces of organic material which could be pyrogen forming is eliminated by oxidation thereof.

REFERENCES:
patent: 3328304 (1967-06-01), Globus
patent: 3452049 (1969-06-01), Globus
Phy. Desk Ref., (PDR), 38th ed., p. 993, (1984).
CRC Handbook of Chem. & Physics, (CRC Handbook), 60th ed., pp. B-68 and B-220, (1979).
U.S. Pharmacopedia-Nat'l Formulary, 15th ed., p. 1044.

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