Method for preparing thienylacetic acids

Details Method for preparing thienylacetic acids Method for preparing thienylacetic acids

1978-01-12

1979-12-25

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 72, C07D33324, C07D33338

Patent

active

041805100

ABSTRACT:
A method for preparing thienylacetic acid and its derivatives is disclosed, wherein a glyoxylic ester is made to react with hydrazine, and after with potash. Advantageously, the glyoxylic ester is prepared by condensation of a monoester monochloride of oxalic acid upon a thiophenic derivative, in the presence of titanium chloride.
The so obtained products are useful as organic synthesis intermediaries for various products of pharmaceutical type.

REFERENCES:
Blicke et al., J.A.C.S., vol. 66, pp. 1645-1648 (1944).
Olah, editor, "Friedel-Crafts and Related Reactions" vol. 1, pp. 201 (1963).
Morrison & Boyd, "Organic Chemistry," 3rd Ed., pp. 625-627, 1008 (1973).

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