Method for preparing swainsonine

Details Method for preparing swainsonine Method for preparing swainsonine

1997-10-03

1999-07-06

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549320, 546183, C07F 702, C07D22102, C07D31718

Patent

active

059199520

ABSTRACT:
(-)-Swainsonine may be prepared by (i) reacting a compound of formula (8): ##STR1## wherein OMs is methanesulfonyl with H.sub.2 in the presence of Pd(OH).sub.2 followed by NaOMe, to obtain a compound of formula (9): ##STR2## and (ii) reducing the carbonyl group and hydrolyzing the ketal group in the compound of formula (9) to obtain (-)-swainsonine of formula (1): ##STR3##

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