Method for preparing substituted nitrogen-heterocyclic compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544219, C07D25130

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active

053129180

ABSTRACT:
Halo-displacement reaction products of aliphatic hydroxy compounds and chloro- or bromo-substituted aromatic nitrogen-heterocyclic compounds are conducted under alkaline conditions in the presence of a phase transfer catalyst, in the substantial absence of water inorganic salts other than those formed in the reaction. The method is particularly useful for the preparation of substituted chlorotriazines. In a preferred embodiment, the reagents constitute at least about 25% by weight of the organic phase of the reaction mixture.

REFERENCES:
patent: 4895945 (1990-01-01), Brown et al.
Heterocyclic Chemistry, Albert, pp 50-53, 116, The Athlone Press, 1968.
Synthesis, Alsaidi et al, pp. 921-924, 1980.

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