Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1995-06-07
1998-07-07
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544257, 544285, 544286, 544287, 544311, 546141, 546243, 546246, 548477, 548546, C07D47310, C07D23980, C07D21194, C07D20948
Patent
active
057771170
ABSTRACT:
Disclosed is a process for preparing compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a terminal moiety comprising a substituted or unsubstituted, oxidized or reduced ring system, the ring system having a single ring or two to three fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.
REFERENCES:
patent: 3124579 (1964-03-01), Yoshida et al.
patent: 3422107 (1969-01-01), Mohler et al.
patent: 3737433 (1973-06-01), Mohler et al.
patent: 4247710 (1981-01-01), Tilley
patent: 4515795 (1985-05-01), Hinze et al.
patent: 4576947 (1986-03-01), Hinze et al.
patent: 4636507 (1987-01-01), Kreutzer et al.
patent: 4668786 (1987-05-01), Thiele et al.
patent: 4833146 (1989-05-01), Gebert et al.
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5039666 (1991-08-01), Novick, Jr.
patent: 5096906 (1992-03-01), Mandell et al.
Bianco et al., Blood, 76:Supplement 1 (522), p. 133a, "Pentoxifylline (PTX) and GM-CSF Decrease Tumor Necrosis Factor-ALPHA (TNF-.alpha.) Levels in Patients Undergoing Allogeneic Bone Marrow Transplantation (BMT)," 1991.
Davis et al., Applied Environment Microbial., 48:2, pp. 327-331, "Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxidation of Pentoxifylline," Aug. 1984.
Fuhrer et al., J. Med. Chem., vol. 27, pp. 831-836, ".beta.-Adrenergic Blocking Agents: Substituted Phenylalkanolamines. Effect of Side-Chain Length on .beta.-Blocking Potency in Vitro", 1984.
Golding et al., "Reaction between Vicinal Diols and Hydrogen . . . ," J. Chem. Soc. Perkin Trans. 1, 1973, pp. 1214-1220.
Carey et al., Advanced Organic Chemistry, 3rd Ed., Part B: Reactions and Synthesis, 1990, pp. 625-626.
Klein J. Peter
Kumar Anil M.
Underiner Gail E.
Cebulak Mary C.
Cell Therapeutics Inc.
Dees Jos,e G.
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