Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1993-11-08
1997-01-21
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
424 951, 424 952, A61K 4900
Patent
active
055957234
ABSTRACT:
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
REFERENCES:
patent: 3898843 (1976-11-01), Chabert et al.
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hillman et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4718433 (1988-01-01), Feinstein
patent: 4767610 (1988-08-01), Long
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4859363 (1989-08-01), Davis et al.
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4895876 (1990-01-01), Schweighardt et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 4993415 (1991-02-01), Long
patent: 5078146 (1992-01-01), Sato
patent: 5080885 (1992-01-01), Long, Jr.
patent: 5088499 (1992-02-01), Unger
patent: 5107842 (1992-04-01), Levene et al.
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5155215 (1992-10-01), Ranney
patent: 5171755 (1992-12-01), Kaufman et al.
patent: 5205290 (1993-04-01), Unger
patent: 5260496 (1993-11-01), Meinert et al.
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5281408 (1994-01-01), Unger
patent: 5284645 (1994-02-01), Long
patent: 5344930 (1994-09-01), Riess et al.
patent: 5354549 (1994-10-01), Klaveness et al.
patent: 5385147 (1995-01-01), Anderson et al.
patent: 5393513 (1995-02-01), Long, Jr.
patent: 5401493 (1995-03-01), Lohrmann et al.
patent: 5406950 (1995-04-01), Brandenburger et al.
Grant & Hackh's Chemical Dictionary, p. 36, 1987.
Mattrey, R. F., et al., Gas Emulsions as Ultrasound Contrast Agents Preliminary Results in Rabbits and Dogs, Investigative Radiology, 29: S139-S141 (Jun. Supplement 1994).
Meltzer, R. S., et al., Transmission of Ultrasonic Contrast Through the Lungs, Ultrasound in Med. & Biol., Vo. 7, No. 4, pp. 377-384 (1981).
Ophir, J., et al., Contrast Agents in Diagnostic Ultrasound, Ultrasound in Medicine and Biology, 15:319-333 (1989).
Swanson, D. P., et al., Pharmaceuticals in Medical Imaging; Radiopaque Contrast Media Radiopharmaceuticals Enhancement Agents for Magnetic Resonance Imaging and Ultrasound, Macmillian Publishing Co., Inc., pp. 682-685 (1990).
Serratrice, G., et al., Co-Solubilisation De Flourocarbures et D'eau en Presence De Nouveaux Tensioactifs Non Ioniques Fluores, Journal Chem. Phys. 87:1969-1980 (1990).
Szonyi, F., et al., Syntheses De Tensioactifs F-Alkyles Non Ioniques Monodisperses, Journal of Fluorine Chemistry, 36:195-209 (1987).
Keller et al., "Ultrasound Backscatter Characteristics of Sonicated Echo Contrast Agents," American Heart Association Abstracts, Pt. III, vol. 72, No. 4, p. 1705. (Oct. 1985).
Widder et al., "Microbubbles as a Contrast Agent for Neurosonography and Ultrsound-Guided Catheter Manipulation: In Vitro Studies," AJR, pp. 347-352. (Aug. 1985).
Keller et al., "Successful Left Ventricular Opacification Following Peripheral Venous Injection of Sonicated Contrast Agent: An Experimental Evaluation," American Heart Journal, vol. 115, No. 4, pp. 570-575. (Sep. 1987).
English Translation by Nissim Marshall, Encyclopedie Des Gaz (gas Encyclopedia). (1976).
Ziskin, et al., "Constrast Agents for Diagnostic Ultrasound," Investigative Radiology, vol. 7, No. 6, pp. 500-505. (Nov.-Dec. 1972).
Feinstein, et al., "Safety and Efficacy of a New Transpulmonary Ultrasound Contrast Agent: Initial Multicenter Clinical Results," JACC, vol. 16, No. 2, pp. 316-324. (Aug. 1990).
Epstein, et al., "On the Stability of Gas Bubbles in Liquid-Gas Solutions," The Journal of Chemical Physics, vol. 18, No. 11, pp. 1505-1509. (Nov. 1950).
Meltzer, et al., "Why Do the Lungs Clear Ultrasonic Constrast?" Ultrasound in Medicine and Biology, vol. 6, No. 3, pp. 263-269. (1980).
N. de Jong, et al. Ultrasonics 1991, vol. 29, Jul. pp. 324-330 "Principles and Recent Developments in Ultrasound Contrast Agents".
N. de Jong et al. Ultrasonics 1992, vol. 30 No. 2. pp. 95-103 "Absorption and Scatter of Encapsulated Gas Filled Microsphers: Theoretical Considerations and Some Measurements".
Journal of Clinical & Laboratory Research Investigative Radiology, "Proceedings of The Association of University Radiologists Annual Meeting 1982", Jul.-Aug. 1982, vol. 17, No. 4, p. S28.
Mattrey et al., "Perfluoroctylbromide: A Liver/Spleen-Specific and Tumor-Imaging Ultrasound Contrast Material", Radiology 145:759-762, Dec. 1982.
Long, Jr. et al., "Experiments with Radiopaque Perfluorocarbon Emulsions for Selective Opacification of Organs and Total Body Angiography", Investigative Radiology, May-Jun., 1980, vol. 15, pp. 242-247.
Zarff et al., "Synergistic Stabilization of Perfluorocarbon-Pluronic F-68 Emulsion by Perfluoroalkylated Polyhydroxylated Surfactants", JAOCS, vol. 66, No. 10 (Oct. 1989).
Varesoon et al., "An Easy, Convenient Way of Describing the Stability of Fluorocarbon Emulsions", Journal de chimie physique, 1989, 86,n.degree. 10, pp. 2111-2116.
Handa et al., "Phospholipid Monolayers at the Triolein-Saline Interface: Production of Microemulsion Particles and Conversion of Monolayers to Bilayers" Biochemistry 1990 29, pp. 2884-2890.
A. S. Kabalnov, et al., "Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability" J. Fluorine Chemistry, 50:271-284 (1990).
H. J. Bleeker, et al., "Ultrasonic characterization of Albunex, a new contrast agent," J. Accoust. Soc. Am. 87(4) (1990).
R. Schlief, "Ultrasound contrast agents," Current Opinion in Radiology 3:198-207 (1991).
H. Bleeker, et al., "On the Application of Ultrasonic Contrast Agents for Blood Flowmetry and Assessment of Cardiac Perfusion," J. Ultrasound Med 9:461-471 (1990).
T. Ohta, et al., "Effect of the Contrast Agent and the Agitation Method on the Size, Number and Stability of Microbubbles: A Basic Experiment for the Myocardial Contrast Study," Jpn J Med Ultrasonics, 18:318-325 (1991).
S. B. Feinstein, et al., "Myocardial Contrast Echocardiography: Examination of Intracoronary Injections, Microbubble Diameters, and Video-Intensity Decay," Am. J. Physio. Imaging 1:12-18 (1986).
P. L. Davis, et al., "Echogenicity Caused by Stable Microbubbles in a Protein-Lipid Emulsion," Clin. Ultrasound 9:249-252 (1981).
V. F. Fobbe, et al., "Farbkodierte Duplexsonographic und Ultraschallkonstrastmittel--Nachweis von renalen Perfusionsdefekten im Tierexperiment", Fortschr. Rontgenstr. 154.3 242-245 (1991).
M. R. Violante, et al., "Particle-Stablized Bubbles for Enhanced Organ Ultrasound Imaging," Invest. Radiology 26:194-200 (1991).
Cebulak Mary C.
Prior Kimberly J.
Sonus Pharmaceuticals
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