Method for preparing stem cell preparations

Details Method for preparing stem cell preparations Method for preparing stem cell preparations

2002-03-15

2009-06-09

Romeo, David S (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S368000, C435S352000, C435S353000, C435S354000, C424S093100

Reexamination Certificate

active

07544509

ABSTRACT:
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues.

REFERENCES:
patent: 5851832 (1998-12-01), Weiss et al.
patent: WO 93/01275 (1993-01-01), None
patent: WO 94/09119 (1994-04-01), None
patent: WO 94/10292 (1994-05-01), None
patent: WO 94/16718 (1994-08-01), None
patent: WO 95/12665 (1995-05-01), None
patent: WO 95/13364 (1995-05-01), None
patent: WO 97/41208 (1997-11-01), None
patent: WO 99/56759 (1999-11-01), None
Shamblott, et al., (1998). Proc. Natl. Acad. Sci. USA 95, 13726 13731.
Shamblott et al., Proc Natl Acad Sci U S A. Jan. 2, 2001; 98(1): 113-118.
Freshney, R.I. 1993. Culture of Animal Cells. A Manual of Basic Techniques, 3rd ed. Wiley-Liss, New York pp. 216-225.
Anderson, D.J. Stem cells and transcription factors in the development of the mammalian neural crest.FASEB J. 8, 707-713 (Jul. 1994).
Arsenijevic, Y. & Weiss, S. Insulin-Like Growth Factor-1 is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor.J. Neurosci. 18, 2118-2128 (Mar. 15, 1998).
Arsenijevic, Y. et al. Insulin-Like Growth Factor-1 is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2.J. Neurosci. 21, 7194-7202 (Sep. 15, 2001).
Auerbach, J.M. et al. Transplanted CNS stem cells form functional synapses in vivo.Eur. J. Neurosci. 12, 1696-1704 (May 2000).
Avoli, M. et al. Pharmacology and Electrophysiology of a Synchronous Gaba-Mediated Potential in the Human Neocortex.Neurosci. 62, 655-666 (1994).
Bamji, S. et al. Comparison of the Expression of a Talpha1:nlacZ Transgene and Talpha1 alpha-Tubulin mRNA in the Mature Central Nervous System.J. Comp. Neurol. 374, 52 (1996).
Bellows, C.G. et al. Determination of Numbers of Osteoprogenitors present in Isolated Fetal Rat Calvaria Cells In Vitro.Dev. Biol. 133, 8-13 (1989).
Bjornson, C.R.R. et al. Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo.Science283, 534-537 (1999).
Bruckenstein, D.A. & Higgins, D. Morphological Differentiation of Embryonic Rat Sympathetic Neurons in Tissue Culture.Dev. Biol. 128, 324-336 (1988).
Brustle, O. et al. Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants.Science285, 754-756 (Jul. 30, 1999).
Burns, S. et al. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine.PNAS80, 4546-4550 (1983).
Calof et al. Analysis of Neurogenesis in a Mammalian Neuroepithelium: Proliferation and Differentiation of an Olfactory Neuron Precusor in Vitro.Neuron3, 315 (1989).
Cameron, H.A. & McKay, R. Stem cells and neutogenesis in the adult brain.Curr. Opin. Neurobiol. 8, 677-680 (Oct. 1998).
Carlsson, A. et al. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists.Nature180, 1200 (1957).
Clarke, D.L. et al. Generalized Potential of Adult Neural Stem Cells.Science288, 1660-1663 (2000).
Daadi, M. et al. Activin Co-operates with Fibroblast Growth Factor 2 to Regulate Tyrosine Hydroxylase Expression in the Basal Forebrain Ventricular Zone Progenitors.Neurosci. 86, 867-880 (Oct. 1998).
Daadi, M.M. & Weiss, S. Generation of Tyrosine Hydroxylase-Producing Neurons form Precursors of the Embryonic and Adult Forebrain.J. Neurosci. 19, 4484-4497 (Jun. 1999).
Dunnet, S.B. et al. Nigral transplants in primate models of parkinsonism.Intracereb. Transplant. Movem. Disord., O. Lindvall, et al., eds. Restorative Neurology 4, 27-51 (1991).
Ehringer, H. et al. Verteilung von noradrenalin und dopamine (3-hydroxytyramin) im gehim des menschen und ihr verhalten bei erkrankungen des extrapyramidalen systems.Kllin. Wschr. 38, 1236-1239 (1960).
Fahn, S. Fetal-tissue Transplants in Parkinson's Disease.N.E. J. Med. 327, 1589-1590 (1992).
Ferrari, G. et al. Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors.Science279, 1528-1530 (1998).
Forsberg-Nilsson, K. et al. Platelet-Derived Growth Factor Induces Chemotaxis of Neuroepithelial Stem Cells.J. Neurosci. Res. 53, 521-530 (Sep. 1998).
Friachard et al. In vitro differentiation of embryonic stem cells into glial cells and functional neurons.J. Cell. Sci. 108, 3181-3185 (1995).
Gage, F.H. et al. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.PNAS92, 11879-11883 (1995).
Gloster, A. et al. The T-alpha1 alpha-Tubulin Promoted Specific Gene Expression as a Function of Neuronal Growth and Regeneration in Transgenic Mice.J. Neurosci. 14, 7319-7330 (1994).
Greenwood, A.L. et al. Identification of dividing, determined sensory neuron precursors in the mammalian neural crest.Development126, 3545-3559 (Aug. 1999).
Gussoni, E. et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation.Nature401, 390-394 (1999).
Huard, J.M.T. et al. Adult Olfactory Epithelium Contains Multipotent Progenitors that Give Rise to Neurons and Non-Neural Cells.J. Comp. Neurol. 400, 469-486 (Nov. 2, 1998).
Kaufman, S.J. et al. Replicating myoblasts express a muscle-specific phenotype.PNAS85, 9606-9610 (1988).
Keirstead, H.S. et al. Polysialylated Neural Cell Adhesion Molecule-Positive CNS Precursors Generate Both Oligodendrocytes and Schwann Cells to Remyelinate the CNS after Transplantation.J. Neurosci. 19, 7529-7536 (1999).
Kessler, P.D. & Byrne, B.J. Myoblast Cell Grafting into Heart Muscle: Cellular Biology and Potential Applications.Ann. Rev. Physiol. 61, 219-242 (1999).
LaBonne, C. & Bronner-Fraser, M. Induction and Patterning of the Neural Crest, a Stem Cell-Like Precursor Population.J. Neurobiol. 36, 175-189 (1998).
Langston, J.W. et al. Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis.Science219, 979-980 (1983).
Lee, S.H. et al. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.Nat. Biotechnol. 18, 675-679 (Jun. 2000).
LeGal La Salle, G. et al. An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain.Science259, 988-990 (1993).
Lumelsky, N. et al. Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets.Science292, 1389-1394 (May 18, 2001).
Lundberg, C. et al. Survival, Integration, and Differentiation of Neural Stem Cell Lines after Transplantation to the Adult Rat Striatum.Exp. Neurol. 145, 342-360 (Jun. 1997).
Mayo, M.L. et al. Desmin expression during early mouse tongue morphogenesis.Int. J. Dev. Biol. 36, 255-263 (1992).
McKay, R. Stem Cells in the Central Nervous System.Science276, 66-71 (Apr. 4, 1997).
McKay, R. Stem cells—hype and hope.Nature406, 361-364 (Jul. 27, 2000).
Morrison, S.J. et al. Prospective Identification, Isolation by Flow Cytometry, and In Vivo Self-Renewal of Multipotent Mammalian Neural Crest Stem Cells.Cell96, 737-749 (Mar. 5, 1999).
Morrison, S.J. et al. Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells.Cell101, 499-510 (May 26, 2000).
Morshead, C.M. et al. Neural Stem Cells in the Adult Mammalian Forebrain: A Relatively Quiescent Subpopulation of Subependymal Cells.Neuron13, 1071-1082 (Nov. 1994).
Mujtaba, T. et al. A Common Neural Progenitor for the CNS and PNS.Dev. Biol. 200, 1-15 (1998).
Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium.Nature410, 701-705 (Apr. 5, 2001).
Ourednik, v. et al. Developmental Biology: Frontiers for Clinical Genetics.Clin. Genet. 56, 267-278 (1999).
Peel, A.L. & Feldman, D.H. Co-localization of glial and neuronal markers in RGF-generated cultures of pluripotent CNS stem cells.Society Neurosci. 21, 285:122.6 (1995).
Pereira, R.F. et al. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in ir

Affiliated with

Also associated with

Rating

Method for preparing stem cell preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing stem cell preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing stem cell preparations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4136519