Method for preparing solid enteric pharmaceutical preparation

Details Method for preparing solid enteric pharmaceutical preparation Method for preparing solid enteric pharmaceutical preparation

1995-08-15

1998-05-12

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424461, 424463, 424480, 427 214, 427 221, 514952, 514781, A61K 936, A61K 962

Patent

active

057501483

ABSTRACT:
A cellulosic enteric base is dissolved in an organic solvent capable of being admixed with water in any rate or a mixed solvent of the organic solvent and water to give a polymer solution, followed by mixing the polymer solution with water, then removing the organic solvent to give a concentrate; adding an anionic surfactant to the concentrate and then drying to give polymer powder. The polymer powder is introduced into water to give an emulsion containing polymer particles having an average particle size of not more than 1 .mu.m and the emulsion is dispersed in water containing a plasticizer to give a coating liquid. A drug is coated with the coating liquid to give a solid enteric pharmaceutical preparation.

REFERENCES:
patent: 4330338 (1982-05-01), Banker
Chemical & Pharmaceutical Bulletin, vol. 41, No. 2, Feb. 1993, Tokyo JP pp. 329-334, XP000354418, Shinji Narisawa et al., "Porosity-Controlled Ethylcellulose Film Coating. I. Formation of Porous Ethylcellulose Film in the Casting process and Factors Affecting Film-Density".
Patent Abstracts of Japan, C-269, Mar. 6, 1985, vol. 9, No. 52.

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