Method for preparing small vesicles using microemulsification

Details Method for preparing small vesicles using microemulsification Method for preparing small vesicles using microemulsification

1985-01-31

1988-06-28

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

264 41, 264 46, 424420, 424450, 436829, A61K 4300, A61K 4900, B01J 1302

Patent

active

047537884

ABSTRACT:
A method is provided for preparing small (less than 2000 .ANG.) lipid vesicles in commercial quantities by microemulsifying lipid compositions using very high shear forces generated in a homogenizing apparatus operated at high pressures at a selected temperature. These vesicles are suitable for various biological applications including targeting of tumors in a body for diagnosis and treatment.

REFERENCES:
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4411894 (1983-10-01), Schrank et al.
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4544545 (1985-10-01), Ryan et al.
Gregorladis: "The Carrier Potential of Liposomes in Biology and Medicine", The New England Journal of Medicine, vol. 295, No. 13, Sep. 23, 1976, pp. 704-710.

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