Method for preparing salts of 6-chloropurine

Details Method for preparing salts of 6-chloropurine Method for preparing salts of 6-chloropurine

1981-03-02

1983-09-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

424253, C07D47340

Patent

active

044057814

ABSTRACT:
There is described a novel method for preparing and isolating novel salts of 6-chloropurine and strong acids. According to the method hypoxanthine is reacted with phosphorus oxychloride in the presence of an organic base to form 6-chloropurine, a solvent is added to the reaction mixture and the latter is reacted with a strong acid to form a 6-chloropurine salt which is then isolated. In a preferred embodiment 6-chloropurine is freed from the salt with water, preferably in the presence of a base. In another preferred embodiment the 6-chloropurine is aminated with various amines.

REFERENCES:
patent: 598502 (1898-02-01), Fisher
patent: 2746961 (1956-05-01), Hitchings
patent: 2832781 (1958-04-01), Hitchings et al.
patent: 3314938 (1967-04-01), Kawashima et al.
patent: 3517006 (1970-06-01), Fujimoto et al.
Ferguson, Textbook of Organic Chemistry, pp. 266-267 (1965).
Nasutavicus et al., J. Het. Chem., 11, 77-78 (1974).
Bendich et al., J.A.C.S., 76 6073-6077 (1954).
Beaman et al., J. Appl. Chem., 12, 432-437 (1962).
CA, 67, 82224w (1967).

Affiliated with

Also associated with

Rating

Method for preparing salts of 6-chloropurine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing salts of 6-chloropurine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing salts of 6-chloropurine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-589170