Method for preparing (+)S-2--hydroxy-2-methyl-hexanoic acid

Details Method for preparing (+)S-2--hydroxy-2-methyl-hexanoic acid Method for preparing (+)S-2--hydroxy-2-methyl-hexanoic acid

1986-08-11

1987-05-26

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

544105, C07C 5901

Patent

active

046688226

ABSTRACT:
A method for preparing an important stereo-specific intermediate in the synthesis of prostaglandin analogs is disclosed. Said intermediate is (+)S-2-hydroxy-2-methyl-hexanoic acid and is prepared via an asymmetric halolactonization reaction utilizing L-proline as the chiral agent.

REFERENCES:
Terashima et al. I, Chemistry Letters, pp. 1109-1112, (1977).
Terashima et al. II, Tetrahedron Letters, No. 11, pp. 1005-1008, (1977).
Jew et al. I, Tetrahedron, vol. 35, pp. 2337-2343, (1979).
Jew et al. II, Tetrahedron, vol. 35, pp. 2345-2352 (1979).
Koga et al., Chemical Abstracts, vol. 90, No. 121225u, (1979).
Marshalok et al., Chemical Abstracts, vol. 95, No. 61428d, (1981).

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