Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1987-01-22
1989-05-02
Maples, John S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
424 11, 252644, 252645, C07F 1300, A61K 4900
Patent
active
048269611
ABSTRACT:
A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.
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Abrams Michael J.
Davison Alan
Jones Alun G.
Bronstein Sewall P.
Maples John S.
Massachusetts Institute of Technology
Neuner George W.
President and Fellows of Harvard College
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