Method for preparing rabbit monoclonal antibodies, the cell line

Details Method for preparing rabbit monoclonal antibodies, the cell line Method for preparing rabbit monoclonal antibodies, the cell line

1985-05-03

1989-08-22

Tarcza, John E.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

43524027, 435948, 935110, 935102, C12N 1500, C12N 500, C12R 191

Patent

active

048595950

ABSTRACT:
A new continuous rabbit cell line, designated TP-3, and variants thereof, which are hypoxyxanthineguanine-phosphoribosyl transferase deficient, hypoxyxanthine-aminopterine-thymidine sensitive, fast growing and non-antibody producing, and the methods for preparing the TP-3 cell line. Also, rabbit-rabbit hybrid cells formed by fusing the TP-3 cell line with antibody-producing cells from immunized rabbits, which hybrid cells are hypoxyxanthine-aminopterine-thymidine insensitve and secrete rabbit antibodies, and the methods for preparing the hybrid cells and hybrid cell lines. The invention further comprises rabbit monoclonal antibody.

REFERENCES:
patent: 4491632 (1985-01-01), Wands et al.
Dreher et al., Journal of Immunology 130(1), pp. 442-448 (1983).
Braun et al., Hoppe-Seyler's Z. Physiol. Chem., 360(5) pp. 663-678, (1979), Biological Abst. 68:53873.
Hoebeke et al., Dev. Immunol. 18, p. 307-11 (1983), Chemical Abst. 100:17099v.
Kohler and Milstein, Nature, 256 495-497 (1975).
J. J. Collins et al., P.N.A.S., 71, 260-263 (1974).
A. D. Strosberg et al., P.N.A.S., 71, 263-265 (1974).
Petit-Koskas et al., Eur. J. Immunology, 11, 388-92 (1981).

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