Method for preparing pyrimidin-2-ylacetic acid esters

Details Method for preparing pyrimidin-2-ylacetic acid esters Method for preparing pyrimidin-2-ylacetic acid esters

1997-07-08

1998-10-13

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544319, C07D23934, C07D23926

Patent

active

058213686

ABSTRACT:
A method for preparing pyrimidin-2-ylacetic acid esters of the general formula: ##STR1## wherein R is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl, aryl or arylalkyl and R.sup.1 to R.sup.3, independently of one another, are hydrogen, C.sub.1-6 -alkyl, fluorinated C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, (C.sub.1-6 -alkoxy)-C.sub.1-6 -alkyl or (C.sub.1-6 -alkoxy)carbonyl. These esters are obtained from the corresponding 2-(halomethyl)-pyrimidine, the corresponding alcohol ROH and carbon monoxide in the presence of a palladium-phosphine complex and a base. Pyrimidin-2-ylacetic acid esters are intermediates in the preparation of herbicides.

REFERENCES:
patent: 5322959 (1994-06-01), Wu
Wada, A., et al., Synthesis, Stuttgart, Germany, (Jul. 7, 1986), pp. 555-556.

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